|
 
 |
| TEACHING IMAGES |
|
| Year : 2013 | Volume
: 1
| Issue : 2 | Page : 197-198 |
|
Pyoderma gangrenosum
Mukhtar Ahmed Bendigeri1, Manjunath M Shenoy2, Banavasi S Girisha1
1 Department of Dermatology, General Medicine, Yenepoya Medical College, Yenepoya University, Deralakatte, Mangalore, Karnataka, India
2 Department of Dermatology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore, Karnataka, India
| Date of Web Publication | 13-Dec-2013 |
Correspondence Address:
Manjunath M Shenoy
Department of Dermatology, Yenepoya Medical College, Nithyananda Nagara, Deralakatte, Mangalore - 575 018, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2321-4848.123054
How to cite this article:
Bendigeri MA, Shenoy MM, Girisha BS. Pyoderma gangrenosum. Arch Med Health Sci 2013;1:197-8 |
| Case Report | |  |
A 35-year-old lady presented with recurrent ulcerations over the lower extremities since 6 months. They were painful and rapidly progressive ulcers, and were characterized by the presence of violaceous undermined borders and necrotic centers [Figure 1]. They heal slowly with treatment leading to cribriform scarring [Figure 2]. Skin biopsy from the edge of the ulcer revealed ulcerated epidermis with central necrosis along with massive infiltration of neutrophils in the dermis; there was no leukocytoclasia or vasculitis. Diagnosis of pyoderma gangrenosum (PG) was made based on the clinical findings supported by the histology depicting a neutrophilic dermatosis. | Figure 1: Rapidly progressive ulcer with necrotic base and violaceous margins
Click here to view |
| Discussion | | |
PG is a rare neutrophilic dermatosis of unknown etiology characterized by severe tissue destruction and ulceration. It is more frequent in females and can occur at any age. It can occur on any cutaneous surface, but most commonly on the lower legs with preference for the pre-tibial area. [1] Many patients have associated systemic diseases like rhematological diseases, inflammatory bowel disease, and malignancies, especially hematological. [2] Thus, PG can be considered as a cutaneous marker of an underlying serious internal disorder. Ulceration is the most common presentation of PG, but it may present as bullous, pustular, or vegetative lesion. [2] Therapy is difficult and requires systemic immunosuppression using agents like steroids, cyclosporine, mycophenolate, tacrolimus, and infliximab.
| References | | |
| 1. | Wollina U. Pyoderma gangrenosum - a review. Orphanet J Rare Dis 2007;2:19. 
[PUBMED] |
| 2. | Brooklyn T, Dunnill G, Probert C. Diagnosis and treatment of pyodermagangrenosum. BMJ 2006;333:181-4.
[PUBMED] |
[Figure 1], [Figure 2]
|
Search Pubmed for