Archives of Medicine and Health Sciences

: 2019  |  Volume : 7  |  Issue : 2  |  Page : 254--257

Ophthalmological perspectives of toxic epidermal necrolysis

Gayatree Mohanty, Shovna Dash, Manoj Kumar, Devanshi Desai 
 Department of Ophthalmology, Kalinga Institute of Medical Sciences and Pradyumna Bal Memorial Hospital, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. Shovna Dash
Plot No. 57/353, Jaydev Vihar, Bhubaneswar - 751 013, Odisha

Toxic epidermal necrolysis (TEN) is as rare as two cases per million per year, but the ocular manifestations and sequelae are very severe. We present a case series of seven patients admitted to the intensive care unit in a tertiary hospital with a diagnosis of TEN describing the extent of ocular involvement, its response to treatment, and appearance of sequelae. All seven were drug-induced with moderate-to-severe skin, mucosal, ophthalmic involvement, and systemic involvement. Ocular findings on presentation were eyelid skin detachment, adherent lid margins, bilateral mucopurulent conjunctivitis with inflammatory membranes, and punctate epithelial keratitis in all patients. Large persistent corneal epithelial defect was seen in four patients. On follow-up, five had severe keratoconjunctivitis sicca and entropion with trichiasis. Photophobia was the major debilitating sequelae. Early management was the key to reduce severity, cicatrization, and sequelae. Corticosteroids topically and systemically, topical cyclosporine, and lubricants were the mainstay of management.

How to cite this article:
Mohanty G, Dash S, Kumar M, Desai D. Ophthalmological perspectives of toxic epidermal necrolysis.Arch Med Health Sci 2019;7:254-257

How to cite this URL:
Mohanty G, Dash S, Kumar M, Desai D. Ophthalmological perspectives of toxic epidermal necrolysis. Arch Med Health Sci [serial online] 2019 [cited 2022 May 25 ];7:254-257
Available from:;year=2019;volume=7;issue=2;spage=254;epage=257;aulast=Mohanty;type=0